COMPOSITIONS AND METHODS FOR INHIBITING THE INTERACTION BETWEEN CFTR AND CAL
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United States of America Patent
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Issued Date -
Mar 7, 2013
app pub date -
Nov 5, 2012
filing date -
Oct 22, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
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