Anti-ICAM-1 single domain antibody and uses thereof
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United States of America Patent
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Jan 7, 2014
Grant Date -
Mar 14, 2013
app pub date -
Apr 27, 2011
filing date -
Apr 27, 2010
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Abstract
Anti-ICAM-1 VHH single-domain antibodies (sdAbs) are generated by immunizing a llama with recombinant ICAM-1. These antibodies are linked to an imaging moiety for in vivo or ex vivo imaging of ICAM-1-related pathological conditions including atherosclerotic plaques. The antibodies may also be linked to a therapeutic agent to specifically target and treat ICAM-1-related pathological conditions.
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