METHODS FOR PROMOTING CELL REPROGRAMMING
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United States of America Patent
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app pub date -
May 31, 2012
filing date -
Jun 1, 2011
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Abstract
The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency. Key kinases are identified and key regulation networks involving such kinases are also identified that may be advantageously targeted to significantly increase reprogramming efficiency as well as direct differentiation of induced pluripotent stem (iPS) cells.
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