PEPTIDOMIMETIC MACROCYCLES

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United States of America Patent

SERIAL NO

13497522

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Abstract

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Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.

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Patent Owner(s)

Patent OwnerAddress
AILERON THERAPEUTICS INC281 ALBANY STREET CAMBRIDGE MA 02139

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Han, Jia-wen Newton, US 4 77
Kapeller-Libermann, Rosana Chestnut Hill, US 163 1261
Kawahata, Noriyuki West Roxbury, US 39 1334
Nash, Huw M Concord, US 72 2496
Noehre, Justin Cambridge, US 7 203
Sawyer, Tomi K Southborough, US 81 1787

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