PHARMACEUTICAL COMPOSITION FOR TREATMENT OF OSTEOARTHRITIS
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United States of America Patent
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Issued Date -
Mar 21, 2013
app pub date -
Dec 27, 2011
filing date -
Sep 20, 2011
priority date (Note) -
Abandoned
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Abstract
A pharmaceutical composition including 2-hydroxy-N—[3-(trifluoromethyl)phenyl]benzamide and used for treatment of osteoarthritis is revealed. The pharmaceutical composition inhibits tumor necrosis factor (TNF) induced interferon regulatory factor (IRF). The activated IRF stimulates chondrocytes to secret matrix metalloproteinases, inducible nitric oxide synthase (iNOS), aggrecanases, etc. This leads to loss of collagen II and further causes degradation of proteoglycan. By suppression of signaling pathways of interferon regulatory factor, symptoms are relieved and osteoarthritis is treated.
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