Use of Semaphorin-4D Binding Molecules for Modulation of Blood Brain Barrier Permeability
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United States of America Patent
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Apr 18, 2013
app pub date -
Oct 11, 2012
filing date -
Oct 11, 2011
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Abstract
Provided herein are methods for decreasing blood-brain barrier permeability in a subject with a neuroinflammatory disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its high affinity Plexin-B1 receptor.
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