Process for preparation of optically active compounds using transfer hydrogenation
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United States of America Patent
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Jan 28, 2014
Grant Date -
Apr 18, 2013
app pub date -
Dec 5, 2012
filing date -
Dec 24, 2008
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Abstract
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate.
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