Methods of diagnosing and treating heart failure

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United States of America Patent

PATENT NO 10393754
APP PUB NO 20130101606A1
SERIAL NO

13579797

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Abstract

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This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.

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Patent Owner(s)

Patent OwnerAddress
STICHTING AMSTERDAM UMCAMSTERDAM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kooij, Viola Alphen, NL 1 2
Murphy, Anne M Towson, US 1 2
Stienen, Ger Abcoude, NL 1 2
van, der Velden Jolanda Amsterdam, NL 1 2
Van, Eyk Jennifer E Baltimore, US 34 113
Zhang, Pingbo Ellicott City, US 5 3

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