ENV TRIMER IMMUNOGENS
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United States of America Patent
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Issued Date -
Apr 25, 2013
app pub date -
Jun 29, 2011
filing date -
Jun 30, 2010
priority date (Note) -
Abandoned
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Abstract
Embodiments of the present invention are drawn to pure forms of human or simian immunodeficiency virus trimeric gp120/gp41 Env protein (Env trimers) and methods for making them. These embodiments address the need for an authentic immunogen lacking uncleaved gp160 Env protein and/or other forms of Env, such as gp41 “stumps” dissociated from gp120, which interfere with neutralizing antibody production in a vaccinated subject.
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