Functional vascularization with biocompatible polysaccharide-based hydrogels

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United States of America Patent

PATENT NO 10143776
APP PUB NO 20130102531A1
SERIAL NO

13807502

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Abstract

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Slow vascularization of functional blood limits the transplantation of tissue constructs and the recovery of ischemic and wounded tissues. Blood vessel ingrowth into polysaccharide-based hydrogel scaffolds remains a challenge. A synergistic effect of multiple angiogenic GFs was established; the co-encapsulation of VEGF plus other growth factors induced more and larger blood vessels than any individual GF, while the combination of all GFs dramatically increased the size and number of newly formed functional vessels. Rapid, efficient, and functional neovascularization may be achieved.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITY3400 NORTH CHARLES STREET BALTIMORE MD 21218

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gerecht, Sharon Baltimore, US 27 51
Shen, Yu-I Baltimore, US 3 4
Sun, Guoming Baltimore, US 7 10

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