Pyrido[2,3-b]pyrazine compounds useful as IP receptor agonist

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United States of America Patent

PATENT NO 8754085
APP PUB NO 20130102611A1
SERIAL NO

13388819

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Abstract

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The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed. Examples of compounds of the invention include the compounds according to Formula Ia, or a pharmaceutically acceptable salt thereof, and the compounds of the examples.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS PHARMACEUTICALS UK LIMITED2ND FLOOR THE WESTWORKS BUILDING WHITE CITY PLACE 195 WOOD LANE LONDON W12 7FQ UNITED KINGDOM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Charlton, Steven John Horsham, GB 11 49
Leblanc, Catherine Horsham, GB 54 245
McKeown, Stephen Carl Hitchin, GB 10 138

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