METABOLIC INHIBITOR AGAINST TUMORS HAVING AN IDH MUTATION

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United States of America Patent

APP PUB NO 20130109643A1
SERIAL NO

13697097

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Abstract

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Methods for treating a cancer having a mutant isocitrate dehydrogenase (IDH), including, but not limited to, a malignant low-grade glioma, a secondary glioblastoma, a transforming myeloproliferative disorder (tMPD), and an acute myelogenous leukemia (AML), with a glutaminase inhibitor, including, bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES), are disclosed.

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Patent Owner(s)

Patent OwnerAddress
THE JOHNS HOPKINS UNIVERSITY3400 NORTH CHARLES STREET BALTIMORE MD 21218

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dang, Chi Van Penn Valley, US 2 51
Emadi, Ashkan Bethesda, US 5 51
Riggins, Gregory Joseph White Hall, US 1 51
Seltzer, Meghan Joyce Herndon, US 1 51
Tsukamoto, Takashi Ellicott City, US 127 1564

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