ACTIVATORS OF HUMAN PYRUVATE KINASE

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United States of America Patent

SERIAL NO

13643594

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Abstract

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Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1-NR-L-A2 (I).

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE SUITE 700 MSC 7788 BETHESDA MD 20892-7788

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Auld, Douglas S Beverly, US 10 45
Boxer, Matthew B Frederick, US 12 52
Shen, Min Boyds, US 78 291
Thomas, Craig J Gaithersburg, US 19 64
Walsh, Martin J Carmel, US 35 493

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