THREE-DIMENSIONAL SCAFFOLDS, METHODS FOR FABRICATING THE SAME, AND METHODS OF TREATING A PERIPHERAL NERVE OR SPINAL CORD INJURY
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United States of America Patent
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Apr 1, 2011
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Apr 1, 2010
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Abstract
One aspect of the invention provides a three-dimensional scaffold including at least one layer of highly-aligned fibers. The at least one layer of highly-aligned fibers is curved in a direction substantially perpendicular to a general direction of the fibers. Another aspect of the invention provides a method for fabricating a three-dimensional scaffold. The method includes: electro spinning a plurality of fibers to produce at least one layer of highly-aligned fibers and forming the at least one layer of highly-aligned fibers into a three-dimensional scaffold without disturbing the alignment of the highly-aligned polymer fibers. A further aspect of the invention provides methods for using a three-dimensional scaffold to treat nerve or spinal cord injury.
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