LIPOIC ACID AND NITROXIDE DERIVATIVES AND USES THEREOF
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United States of America Patent
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Issued Date -
May 9, 2013
app pub date -
May 9, 2011
filing date -
May 10, 2010
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Abandoned
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Abstract
Provided are bifunctional compounds comprising a poly(ADP-ribose) polymerase (PARP) inhibitor moiety and a reactive oxygen species (ROS) scavenger moiety, more particularly, a lipoic acid or cyclic nitroxide derivative, covalently attached either directly or via a linker, as well as pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful for prevention, treatment, or management of diseases, disorders and conditions associated with elevated PARP activity or expression.
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