Endoribonuclease compositions and methods of use thereof

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United States of America Patent

PATENT NO 9115348
APP PUB NO 20130130248A1
SERIAL NO

13671120

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Abstract

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The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.

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Patent Owner(s)

Patent OwnerAddress
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA1111 FRANKLIN STREET 5TH FLOOR OAKLAND CA 94607-5200

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Doudna, Jennifer A Berkeley, US 223 4956
Haurwitz, Rachel E Berkeley, US 26 1358
Jinek, Martin Berkeley, US 110 2779
Wiedenheft, Blake Oakland, US 5 610

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