Genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I

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United States of America Patent

PATENT NO 8759032
APP PUB NO 20130130324A1
SERIAL NO

13811340

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A genetically engineered strain WSJ-IA for producing isovaleryl spiramycin I. Also provided is a method for preparing the strain, including the steps of: (a) constructing a recombinant plasmid including a double gene ist-acyB2; (b) transforming the plasmid into an isovaleryl spiramycin I-producing strain to obtain the strain WSJ-IA. The level of isovaleryl spiramycin I produced by fermentation of the strain WSJ-IA is increased 1.7 times and the fermentation potency thereof increased 4.14 times in comparison with the strain exclusively including a single gene ist.

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SHEN YANG FUYANG MEDICINE TECHNOLOGY CO LTDLIAONING PROVINCE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jiang, Yang Shen Yang, CN 28 51
Wang, Yiguang Beijing, CN 20 44
Yang, Shengwu Shen Yang, CN 2 3
Zhao, Xiaofeng Shen Yang, CN 30 38

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