Processes for Making (R)-Ethyl 4-Cyano-3 Hydroxybutyric Acid
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United States of America Patent
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May 23, 2013
app pub date -
Jan 25, 2013
filing date -
Jun 13, 2002
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Abstract
The invention provides novel processes for making ethyl-4-cyano-3-hydroxybutyrate, e.g., (R)-ethyl 4-cyano-3-hydroxybutyric acid, and 4-cyano-3-hydroxybutyric acid. The invention provides protocols for making and 4-cyano-3-hydroxybutyric acid and ethyl-4-cyano-3-hydroxybutyrate by whole cell processes, cell lysate processes, “one pot processes” and “multi-pot” processes using a variety of parameters.
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