Protein and gene biomarkers for rejection of organ transplants

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United States of America Patent

PATENT NO 9535075
APP PUB NO 20130143755A1
SERIAL NO

13635667

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Abstract

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Aspects of the present invention include methods for determining a transplant category of a subject having a transplant. Common mechanisms of rejection injury are uncovered across different tissue transplants, and provide a means to understand rational drug design. Various sources of tissues are examined form the patient for understanding AR mechanism (graft biopsy), as well as monitoring by minimal invasive means (blood) or non-invasive means (urine for the kidney allograft). For biomarker discovery different categories of markers are examined such as genes, proteins, peptides and antibodies. These biomarkers can help determine the subject's transplant category (e.g., acute allograft rejection (AR), stable allograft (STA), BK viremia, BK nephritis, drug toxicity or chronic allograft injury (CAI), and the like). Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications.

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Patent Owner(s)

Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYBUILDING 170 THIRD FLOOR MAIN QUAD P O BOX 20386 STANFORD CA 94305-2038

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Butte, Atul J Menlo Park, US 21 53
Kaushal, Amit Los Altos, US 3 10
Khatri, Purvesh Stanford, US 26 31
Li, Li Fremont, US 1435 18853
Sarwal, Minnie M Portola Valley, US 34 171
Sigdel, Tara Palo Alto, US 9 43
Xiao, Wenzhong San Jose, US 4 10

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