Acid Salt Forms of Polymer-Drug Conjugates and Alkoxylation Methods
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United States of America Patent
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Jun 6, 2013
app pub date -
Nov 18, 2010
filing date -
Nov 18, 2009
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Abstract
Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.
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