Translation Kinetic Mapping, Modification and Harmonization
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United States of America Patent
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Issued Date -
Jun 13, 2013
app pub date -
Oct 30, 2012
filing date -
Oct 31, 2011
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Abandoned
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Abstract
The profile of translation elongation rate along an mRNA is modulated in a directed manner by locally altering codon usage, in particular utilizing differences in ribosomal dwell times among pairs of synonymous codons translated by a single tRNA through wobble base pairing. Unlike codon optimization based on organism-specific codon frequencies or tRNA pools, the methods of the invention need not change the tRNA that translates the codon, rather modulating the interaction between a given tRNA and the mRNA coding sequence.
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