Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides

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United States of America Patent

PATENT NO 8921583
SERIAL NO

13757113

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Abstract

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The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.

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Patent Owner(s)

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ONYX THERAPEUTICS INC249 EAST GRAND AVENUE SOUTH SAN FRANCISCO CA 94080

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fuller, William Dean San Diego, US 3 142
Laidig, Guy J Menlo Park, US 51 1416
Phiasivongsa, Pasit Brentwood, US 53 931
Sehl, Louis C Redwood City, US 17 1070

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