INTRAVAGINAL RING FOR THE DELIVERY OF UNIQUE COMBINATIONS OF ANTIMICROBIAL COMPOSITIONS
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United States of America Patent
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Issued Date -
Jun 13, 2013
app pub date -
Feb 5, 2013
filing date -
Apr 30, 2002
priority date (Note) -
Abandoned
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Abstract
Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretroviral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions. Also disclosed are intravaginal rings for delivering water-soluble compounds, and preferably high molecular weight water-soluble polymers at essentially a zero order rate. The rings include an outer layer of non-water-swellable elastomer, and preferably high molecular weight water-soluble polymer and an inner layer of the water-soluble polymer, which is imbedded in the outer layer, and an aperture through the outer layer for release thereof only through that aperture.
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