RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS
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United States of America Patent
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Nov 20, 2012
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Sep 23, 2002
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Abstract
The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
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