GENETIC MARKERS FOR THE PROGNOSIS OF MULTIPLE SCLEROSIS
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United States of America Patent
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Issued Date -
Jul 18, 2013
app pub date -
Dec 18, 2008
filing date -
Dec 21, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a series of genes the expression of which is altered in subjects suffering multiple sclerosis with respect to healthy subjects or in subjects suffering multiple sclerosis with a good prognosis with respect to subjects suffering multiple sclerosis with a bad prognosis. A subset formed by 13 genes and two clinical variables which allows predicting the progress of a patient with a high reliability has been validated from an initial set of genes which showed said differential expression. From said expression values, the invention provides methods for predicting the progress of a patient diagnosed with multiple sclerosis from tables of conditional probability between the expression levels of a determined gene or group of genes and the probability that the patient has a good or bad prognosis of the disease.
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