METHOD FOR IMPROVING CLEAVAGE OF DNA BY ENDONUCLEASE SENSITIVE TO METHYLATION

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United States of America Patent

APP PUB NO 20130196320A1
SERIAL NO

13704417

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Abstract

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The present invention concerns novel methods for improving cleavage of DNA by rare-cutting endonucleases, overcoming DNA modification constraints, particularly DNA methylation, thereby giving new tools for genome engineering, particularly to increase the integration efficiency of a transgene into a genome at a predetermined location, including therapeutic applications and cell line engineering.

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CELLECTIS75013 PARIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Daboussi, Fayza Chelles, FR 7 13
Duchateau, Philippe Draveil, FR 111 1184
Valton, Julien Paris, FR 37 323

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