PROCESS FOR PRODUCTION OF BIVALIRUDIN
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United States of America Patent
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Issued Date -
Aug 1, 2013
app pub date -
Mar 25, 2013
filing date -
Sep 14, 2005
priority date (Note) -
Abandoned
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Abstract
The invention relates to methods for the preparation of high purity Bivalirudin. The polypeptide is prepared in a high purity of at least 98.5% (by HPLC), wherein the total impurities amount to less than 1.5%, comprising not more than 0.5% [Asp9-Bivalirudin] and each is impurity less than 1.0%, and preferably having a purity of at least about 99.0% by HPLC, wherein the total impurities amount to less than 1.0%, comprising not more than 0.5% [Asp9-Bivalirudin] and each impurity is less than 0.5%.
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