NOVEL BIOMARKERS AND TARGETS FOR OVARIAN CARCINOMA
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United States of America Patent
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Issued Date -
Aug 1, 2013
app pub date -
Apr 22, 2011
filing date -
Apr 22, 2010
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Abstract
Novel biomarkers and targets associated with ovarian cancer, particularly clear-cell carcinoma, endometrioid carcinoma, and uterine carcinoma, are disclosed. Mutations in genes encoding proteins that form part of the SWI/SNF chromatin remodelling protein complex, including ARID1A, or loss of expression of such proteins, including BAF250a, can be used to evaluate the likelihood endometriosis will progress or transform to cancer, to provide a prognosis for a patient with cancer, to assess whether conventional treatment is likely to be effective against a cancer, and/or in a synthetic lethal screen to identify novel targets and therapeutics for the treatment of cancer.
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