METHOD OF STABILIZING mRNA

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United States of America Patent

APP PUB NO 20130203113A1
SERIAL NO

13696885

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Abstract

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There is provided a method to increase the production of a desired protein in a microorganism by introduction of slowly translated codons in the encoding DNA gene sequence capable of slowing down the translation speed of the ribosomes moving along the mRNA, whereby the ribosomes protect the mRNA from being enzymatically degraded. This increases the stability of the mRNA transcript and thus results in an increased production of the desired protein. Moreover, there is provided a method of decreasing the half-life of a mRNA transcript from a gene encoding a peptide.

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Patent Owner(s)

Patent OwnerAddress
KOBENHAVNS UNIVERSITETNORREGADE 10 KOBENHAVN K DK-1017

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lo, Svenningsen Sine Koebenhavn K, DK 1 0
Mitarai, Namiko Koebenhavn N, DK 1 0
Pedersen, Margit Roskilde, DK 13 2
Pedersen, Steen Birkeroed, DK 10 122
Sneppen, Kim Charlottenlund, DK 1 0

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