INHIBITORS OF PDE4 BINDING TO HSP20
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United States of America Patent
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Issued Date -
Aug 15, 2013
app pub date -
Oct 7, 2011
filing date -
Oct 8, 2010
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Abandoned
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Abstract
The present invention provides methods and materials for use in increasing HSP20 activation in a biological system, for example by increasing phosphorylation of Ser16 of HSP20. In one aspect, the invention provides a method for increasing HSP20 activation in a biological system, comprising contacting the system with an antagonist capable of inhibiting PDE4 binding to HSP20, the antagonist comprising or consisting essentially of a fragment of PDE4 or an analogue thereof. In a further aspect the invention provides a method of screening for an agent able to increase activation of HSP20. A preferred antagonist has a C-terminal lysine residue.
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