Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation
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United States of America Patent
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Dec 1, 2020
Grant Date -
Sep 26, 2013
app pub date -
Oct 19, 2012
filing date -
Oct 19, 2011
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Abstract
Pharmaceutical preparations, compositions, systems, and devices including medical devices and diagnostic or therapeutic agents, and methods to treat disease by modification of local tissue environment to modulate the therapeutic index of locally or systemically delivered therapeutic or diagnostic agents. Improved ability to reduce sympathetic nerve activity in the adventitia and perivascular tissues around arteries and veins in the body. Modulation of the local tissue environment around an artery to enable more effective denervation with or without a therapeutic agent. Modulation may include adjustment of the pH of the tissue.
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