MOLECULAR-DETERMINANT BASED TYPING OF KIR ALLELES AND KIR-LIGANDS
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United States of America Patent
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Issued Date -
Oct 10, 2013
app pub date -
Oct 5, 2011
filing date -
Oct 6, 2010
priority date (Note) -
Abandoned
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Abstract
The present invention relates to an assay to perform a molecular determinant-based functional killer immunoglobulin-like receptors (KIR) allele typing and ligand typing. In particular the present invention provides methods, compositions, and kits for a single nucleotide polymorphism (SNP) assay to type various allele groups of KIR2DL1 and KIR ligand with distinct functional properties based on polymorphism at position 245 in KIR2DL1, position 77 in HLA-C, and position 83 in HLA-B and HLA-A. The assays are suitable for use in predicting NK cell activity in health, disease, and transplantation.
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