Treatment of Cancer WIth Dopamine Receptor Antagonists
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United States of America Patent
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Issued Date -
Dec 12, 2013
app pub date -
Feb 28, 2012
filing date -
Feb 28, 2011
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Abandoned
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Abstract
Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and/or subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided.
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