METHOD OF PRODUCING RECOMBINANT IDURONATE-2-SULFATASE
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United States of America Patent
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Jan 2, 2014
app pub date -
Mar 14, 2013
filing date -
Jun 29, 2012
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Abstract
The present invention provides, among other things, methods and compositions for large-scale production of recombinant I2S protein using suspension culture of mammalian cells in serum-free medium. In particular, the present invention uses mammalian cells co-express a recombinant I2S protein and a formylglycine generating enzyme (FGE).
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