PRODUCTION OF MULTIVESICULAR LIPOSOMES
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United States of America Patent
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Issued Date -
Jan 2, 2014
app pub date -
Mar 8, 2013
filing date -
Nov 14, 1997
priority date (Note) -
Abandoned
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Abstract
Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The products produced according to the processes of the invention can be produced through a series of aseptic steps.
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