Importance

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Abstract

Compounds of Formula I are useful for the treatment of anxiety disorders such as generalized anxiety disorder (GAD), panic attack, post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD) and social phobias, wherein: A is chosen from: aryl or heteroaryl, A being optionally substituted with up to 5 independently-selected groups R⁸; R¹ is chosen from: alkyl or haloalkyl; R² is chosen from: H, C(O)R⁶, C(O)OR⁶, SO2R⁶ or C(O)NR⁶R⁷; R³, R⁴ and R⁵ are independently chosen from: H or alkyl; R⁶ and R⁷ are independently chosen from: H or alkyl; and R⁸ is chosen from: OH, CN, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, C(O)R⁶, C(O)OR⁶, SO2R⁶ or C(O)NR⁶R⁷.

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First Claim