Use of Sirt1 Activators or Inhibitors to Modulate an Immune Response
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United States of America Patent
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Issued Date -
Jan 30, 2014
app pub date -
Dec 17, 2012
filing date -
Feb 7, 2008
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Abstract
The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of SIRT1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of SIRT1. The present disclosure provides a method of modulating activation and differentiation of CD4+ T cells.
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