PREPARATION OF DRUG PARTICLES USING EVAPORATION PRECIPITATION INTO AQUEOUS SOLUTIONS
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United States of America Patent
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Issued Date -
Jan 30, 2014
app pub date -
Oct 3, 2013
filing date -
Nov 3, 2000
priority date (Note) -
Abandoned
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Abstract
A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug. The present invention additionally contemplates products and processes for new drug formulations of insoluble drug particles having high dissolution rates and extremely high drug-to-excipient ratios.
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