METHOD FOR THE TREATMENT OR PROPHYLAXIS OF LYMPHANGIOLEIOMYOMATOSIS (LAM) AND ANIMAL MODEL FOR USE IN LAM RESEARCH
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United States of America Patent
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Issued Date -
Feb 20, 2014
app pub date -
Aug 9, 2013
filing date -
May 20, 2008
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Abstract
Treatment of lymphangioleiomyomatosis with the MEK1/2 inhibitor CI-1040 delayed the development of primary tumors and blocked the estrogen-induced lung metastases in treated animals. Such treatment also reduced the number of circulating ELT3 cells and decreased their lung colonization after intravenous injection.
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