Methods and systems for the detection of ricin and other ribosome inactivating proteins

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United States of America Patent

PATENT NO 10907193
APP PUB NO 20140065623A1
SERIAL NO

13898917

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Abstract

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A device, method, and system for the detection of ribosome inactivating protein activity, including the ricin toxin, in a sample. According to one embodiment, the ribosome inactivating protein in the sample removes an adenine from a labeled DNA substrate to create an abasic site. An AP lyase can then cleave the DNA substrate at the abasic site, allowing the fluorophore located at or near one end of the DNA substrate and the quencher at or near the other end of the DNA substrate to spatially separate. Once the fluorophore and the quencher are sufficiently separated, the fluorophore will emit a fluorescence signal. Increasing fluorescence, indicating ribosome inactivating protein activity, will be monitored in real time using a detection system.

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Patent Owner(s)

Patent OwnerAddress
DAIRY ONE COOPERATIVE INC730 WARRANT ROAD ITHACA NY 14850

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chamberlin, Lisa Helen East Syracuse, US 3 4
Doctor, Kenton Arthur East Syracuse, US 5 8
Massulik, Stacey Ann Syracuse, US 3 4
Mills, Jeffrey Harold Liverpool, US 3 4
Moshier, Timothy Francis Fulton, US 5 8
Stites, Frances Louise Ashburn, US 3 4
Suliman, Huda Sirageldin North Syracuse, US 3 4

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