ANTI-CD147 ANTIBODIES, METHODS AND USES
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United States of America Patent
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Issued Date -
Mar 20, 2014
app pub date -
Nov 19, 2013
filing date -
Sep 29, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
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