Serum S100B And Uses Thereof
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United States of America Patent
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Issued Date -
Mar 27, 2014
app pub date -
May 9, 2012
filing date -
May 9, 2011
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention is directed to a method of assessing blood brain barrier permeability in an individual comprising selectively or specifically detecting a level of S 100BB homodimer in a sample of the individual, and comparing the level of S 100BB homodimer in the sample to a level of S 100B a control. The invention is also directed to methods of determining the effectiveness of a treatment for a neurological disorder wherein blood-brain barrier permeability is present in an individual in need thereof comprising detecting a level of S100B in a sample of the individual undergoing the treatment, and comparing the level of S 100B in the sample to the level of S100B in a sample from the individual obtained prior to treatment. The invention is also directed to a method of detecting a history of blood brain barrier disruption in an individual in need thereof comprising detecting autoantibodies directed against S100B in a sample of the individual, wherein the presence of auto-antibodies directed against S100B in the sample indicates that the individual has a history of blood brain barrier disruption.
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