QUINOLONE ANALOGS FOR TREATING AUTOIMMUNE DISEASES

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United States of America Patent

APP PUB NO 20140086839A1
SERIAL NO

14005583

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Abstract

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Provided are methods of treating autoimmune diseases by administering to the subject a therapeutically effective amount of a quinolone compound such as 2-(4-methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide (CX-5461). Also provided are methods of monitoring efficiency of treatment of the quinolone compound by determining the expression level of at least one gene of the RNA polymerase I pathway.

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Patent Owner(s)

Patent OwnerAddress
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD5262000 RAMAT-GAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Achiron, Anat Tel-Aviv, IL 13 90
Gurevich, Michael Rechovot, IL 14 100

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