IL-18 BINDING PROTEINS

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United States of America Patent

APP PUB NO 20140088296A1
SERIAL NO

13870391

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-1 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

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Patent Owner(s)

Patent OwnerAddress
ABBOTT LABORATORIESNORTH CHICAGO IL

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Babcook, John Vancouver, CA 18 229
Ghayur, Tariq Holliston, US 126 2977
Green, Larry San Francisco, US 45 854
Hedberg, Brad Vancouver, CA 4 138
Jia, Xiao-Chi Los Angeles, US 75 1176
Kang, Jaspal Singh Surrey, CA 37 270
Labkovsky, Boris Marlborough, US 57 4037
Voss, Jeffrey W Holden, US 25 509
Wieler, James Beverly, US 8 209

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