Vectors and Methods For Enhancing Recombinant Protein Expression in Plants
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United States of America Patent
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Issued Date -
Mar 27, 2014
app pub date -
Mar 15, 2013
filing date -
Sep 18, 2012
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Abandoned
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Abstract
Expression vectors and methods of their use for enhancing the production of recombinant proteins in plants or plant cells are described. Production can be further enhanced upon co-expression of the P19 suppressor of gene-silencing from tomato bushy stunt virus. Preferably, the recombinant proteins are therapeutic enzymes and/or antibodies and methods are carried out in Nicotiana benthamiana—optionally an RNAi-based glycomodified strain—or in the Nicotiana tabacum cultivar Little Crittenden.
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