PROGNOSTIC AND THERAPEUTIC SIGNATURE FOR MALIGNANT MELANOMA
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United States of America Patent
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Issued Date -
Apr 3, 2014
app pub date -
Mar 30, 2012
filing date -
Apr 1, 2011
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a method of predicting the course of disease in a patient having a malignant melanoma, the method comprising determining in melanoma cells comprised in a sample obtained from said malignant melanoma the presence or amount of at least five biomarkers selected from the group comprising or consisting of MTAP, PTEN, Bax, Bcl-X, β-Catenin, CD20, Cox-2, CD49d and MLH1, wherein the absence or decreased amount of MTAP and β-Catenin and/or the presence or increased amount of PTEN, Bax, Bcl-X, CD20, Cox-2, CD49d and MLH1, is associated with a disadvantageous course of disease.
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