ENGINEERED THREE-DIMENSIONAL CONNECTIVE TISSUE CONSTRUCTS AND METHODS OF MAKING THE SAME
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United States of America Patent
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Apr 10, 2014
app pub date -
Mar 13, 2013
filing date -
Jun 19, 2012
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Abstract
Disclosed are engineered, living, three-dimensional connective tissue constructs comprising connective tissue cells. In some embodiments, the connective tissue cells are derived from multi-potent cells such as mesenchymal stem/stromal cells. In some embodiments, the cells are cohered to one another. In some embodiments, the multi-potent cells have been exposed to one or more differentiation signals to provide a living, three-dimensional connective tissue construct. In some embodiments, the constructs are substantially free of pre-formed scaffold at the time of use. Also disclosed are implants for engraftment, arrays of connective tissue constructs for in vitro experimentation, as well as methods of making the same.
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