HIGH POTENCY SIRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
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United States of America Patent
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Issued Date -
Apr 10, 2014
app pub date -
Aug 21, 2013
filing date -
Feb 1, 2002
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Abandoned
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Abstract
The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.
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