Method of improving microarray performance by strand elimination
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United States of America Patent
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Issued Date -
May 8, 2014
app pub date -
Oct 30, 2013
filing date -
Nov 8, 2012
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Abstract
The invention is a method of determining nucleotide sequence of a target nucleic acid using microarray analysis. Hybridization signals from probe sets corresponding to the sense and anti-sense strands are compared at each nucleotide position. If there is a substantial difference in performance between the two strands, probe sets from a poorly performing stand are eliminated from the sequence determination calculation for a particular nucleotide.
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