TREATMENT AND PROPHYLAXIS OF AMYLOIDOSIS
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United States of America Patent
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Issued Date -
May 15, 2014
app pub date -
Dec 6, 2013
filing date -
Dec 28, 2007
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Abstract
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.
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